Assay Detail
Binding
CHEMBL1063142
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Displacement of [3H]raclopride from rat dopamine D2short receptor expressed in CHO-K1 cells by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.79 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562935 | — | — | 1 | 8.82 |
| CHEMBL560721 | — | — | 1 | 8.70 |
| CHEMBL517028 | — | — | 1 | 8.38 |
| CHEMBL550180 | — | — | 1 | 8.04 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.94 |
| CHEMBL465054 | — | — | 1 | 7.93 |
| CHEMBL564909 | — | — | 1 | 7.85 |
| CHEMBL557547 | — | — | 1 | 7.68 |
| CHEMBL562460 | — | — | 1 | 6.94 |
| CHEMBL550792 | — | — | 1 | 6.72 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562935 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL560721 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL517028 | — | Ki | = | 4.14 | nM | 8.38 |
| CHEMBL550180 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL53 | APOMORPHINE | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL465054 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL564909 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL557547 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL562460 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL550792 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL59 | DOPAMINE | Ki | = | 197.0 | nM | 6.71 |