Assay Detail
Binding
CHEMBL1063782
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Inhibitory constant against ROCK1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.04 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406821 | — | — | 1 | 8.22 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.82 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 6.82 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406821 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL559147 | Y-27632 | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1233300 | HYDROXYFASUDIL | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL38380 | FASUDIL | Ki | = | 530.0 | nM | 6.28 |