Assay Detail
Functional
CHEMBL1065058
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Cytotoxicity against human MDA-MB-361 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-361 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.43 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592461 | — | — | 1 | 8.52 |
| CHEMBL592615 | — | — | 1 | 8.52 |
| CHEMBL592619 | — | — | 1 | 8.52 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 8.40 |
| CHEMBL1204015 | — | — | 1 | 8.01 |
| CHEMBL1204014 | — | — | 1 | 8.00 |
| CHEMBL597825 | — | — | 1 | 7.72 |
| CHEMBL597004 | — | — | 1 | 7.52 |
| CHEMBL605121 | — | — | 1 | 7.44 |
| CHEMBL599258 | — | — | 1 | 7.42 |
| CHEMBL596597 | — | — | 1 | 7.35 |
| CHEMBL604908 | — | — | 1 | 7.25 |
| CHEMBL599259 | — | — | 1 | 6.94 |
| CHEMBL599246 | — | — | 1 | 6.93 |
| CHEMBL597814 | — | — | 1 | 6.70 |
| CHEMBL604303 | — | — | 1 | 6.39 |
| CHEMBL597815 | — | — | 1 | 6.10 |
| CHEMBL597824 | — | — | 1 | 6.09 |
| CHEMBL599668 | — | — | 1 | - |
| CHEMBL599667 | — | — | 1 | - |
| CHEMBL596994 | — | — | 1 | - |
| CHEMBL597012 | — | — | 1 | - |
| CHEMBL596790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592461 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL592615 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL592619 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1204015 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1204014 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL597825 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL597004 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL605121 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL599258 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL596597 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL604908 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL599259 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL599246 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL597814 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL604303 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL597815 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL597824 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL599668 | — | IC50 | - | — | - | |
| CHEMBL599667 | — | IC50 | - | — | - | |
| CHEMBL596994 | — | IC50 | - | — | - | |
| CHEMBL597012 | — | IC50 | - | — | - | |
| CHEMBL596790 | — | IC50 | - | — | - |