Assay Detail
Binding
CHEMBL1065613
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Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy
40
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.36 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599617 | — | — | 2 | 7.00 |
| CHEMBL597562 | — | — | 2 | 6.75 |
| CHEMBL591932 | — | — | 2 | 6.14 |
| CHEMBL605981 | — | — | 2 | 6.06 |
| CHEMBL596757 | — | — | 2 | 5.89 |
| CHEMBL606391 | — | — | 2 | 5.82 |
| CHEMBL599823 | — | — | 2 | 5.59 |
| CHEMBL597360 | — | — | 2 | 5.57 |
| CHEMBL599618 | — | — | 2 | 5.53 |
| CHEMBL590986 | — | — | 2 | 5.37 |
| CHEMBL597561 | — | — | 2 | 5.34 |
| CHEMBL599195 | — | — | 2 | 5.06 |
| CHEMBL603879 | — | — | 2 | 4.66 |
| CHEMBL605348 | — | — | 2 | 4.51 |
| CHEMBL597149 | — | — | 2 | 4.42 |
| CHEMBL598165 | — | — | 2 | 4.33 |
| CHEMBL599196 | — | — | 2 | 4.24 |
| CHEMBL604295 | — | — | 2 | 4.19 |
| CHEMBL605568 | — | — | 1 | - |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | - |
| CHEMBL521 | IBUPROFEN | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599617 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL599617 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL597562 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL597562 | — | IC50 | = | 181.97 | nM | 6.74 |
| CHEMBL591932 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL591932 | — | IC50 | = | 724.44 | nM | 6.14 |
| CHEMBL605981 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL605981 | — | IC50 | = | 870.96 | nM | 6.06 |
| CHEMBL596757 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL596757 | — | IC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL606391 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL606391 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL599823 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL599823 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL597360 | — | IC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL597360 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL599618 | — | IC50 | = | 2951.21 | nM | 5.53 |
| CHEMBL599618 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL590986 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL590986 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL597561 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL597561 | — | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL599195 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL599195 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL603879 | — | IC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL603879 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL605348 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL605348 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL597149 | — | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL597149 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL598165 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL598165 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL599196 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL599196 | — | IC50 | = | 57543.99 | nM | 4.24 |
| CHEMBL604295 | — | IC50 | = | 64565.42 | nM | 4.19 |
| CHEMBL604295 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 260000.0 | nM | - |
| CHEMBL112 | ACETAMINOPHEN | IC50 | > | 300000.0 | nM | - |
| CHEMBL605568 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL521 | IBUPROFEN | IC50 | = | 263026.8 | nM | - |