Compound Detail
CHEMBL590986
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Basic Information
| ChEMBL ID | CHEMBL590986 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTYPLENILVWYIG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
449.8
MW (Da)
5.68
ALogP
5
HBA
2
HBD
80.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 5.37 | 5.37 | 4265.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 4265.8 | nM | 5.37 | Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid... | 20143779 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 4300.0 | nM | 5.37 | Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid... | 20143779 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20143779 | 10.1021/jm901891p | Fatty-acid amide hydrolase 1 | 3 |
| 20143779 | 10.1021/jm901891p | Prostaglandin G/H synthase 1 | 1 |
Data from ChEMBL 36 via Core Engine