Assay Detail
Toxicity
CHEMBL1067385
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Toxicity against rat L6 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.63 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.95 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.92 |
| CHEMBL607530 | — | — | 1 | 5.89 |
| CHEMBL593930 | — | — | 1 | 5.83 |
| CHEMBL593792 | — | — | 1 | 5.82 |
| CHEMBL594246 | — | — | 1 | 5.66 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.49 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.37 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 5.07 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.37 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.23 |
| CHEMBL593018 | — | — | 1 | - |
| CHEMBL593073 | — | — | 1 | - |
| CHEMBL609575 | — | — | 1 | - |
| CHEMBL593231 | — | — | 1 | - |
| CHEMBL593688 | — | — | 1 | - |
| CHEMBL367738 | — | — | 1 | - |
| CHEMBL593094 | — | — | 1 | - |
| CHEMBL408157 | — | — | 1 | - |
| CHEMBL455600 | — | — | 1 | - |
| CHEMBL596112 | — | — | 1 | - |
| CHEMBL595665 | — | — | 1 | - |
| CHEMBL594240 | — | — | 1 | - |
| CHEMBL593072 | — | — | 1 | - |
| CHEMBL608989 | — | — | 1 | - |
| CHEMBL593929 | — | — | 1 | - |
| CHEMBL594467 | — | — | 1 | - |
| CHEMBL594400 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL607530 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL593930 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL593792 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL594246 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL594030 | — | IC50 | = | 152800.0 | nM | - |
| CHEMBL593018 | — | IC50 | = | 159900.0 | nM | - |
| CHEMBL593073 | — | IC50 | = | 173200.0 | nM | - |
| CHEMBL609575 | — | IC50 | = | 118700.0 | nM | - |
| CHEMBL593231 | — | IC50 | = | 132500.0 | nM | - |
| CHEMBL593688 | — | IC50 | = | 235700.0 | nM | - |
| CHEMBL367738 | — | IC50 | = | 178800.0 | nM | - |
| CHEMBL593094 | — | IC50 | = | 299600.0 | nM | - |
| CHEMBL408157 | — | IC50 | = | 390200.0 | nM | - |
| CHEMBL455600 | — | IC50 | > | 290000.0 | nM | - |
| CHEMBL596112 | — | IC50 | > | 290000.0 | nM | - |
| CHEMBL595665 | — | IC50 | > | 340000.0 | nM | - |
| CHEMBL594240 | — | IC50 | > | 490000.0 | nM | - |
| CHEMBL593072 | — | IC50 | > | 680000.0 | nM | - |
| CHEMBL608989 | — | IC50 | > | 680000.0 | nM | - |
| CHEMBL593929 | — | IC50 | > | 680000.0 | nM | - |
| CHEMBL594467 | — | IC50 | > | 680000.0 | nM | - |
| CHEMBL594400 | — | IC50 | > | 680000.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | > | 90000.0 | nM | - |