Assay Detail
Binding
CHEMBL1067759
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Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.37 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.40 |
| CHEMBL210405 | — | — | 1 | 7.30 |
| CHEMBL599658 | — | — | 1 | 7.22 |
| CHEMBL597601 | — | — | 1 | 7.05 |
| CHEMBL437490 | — | — | 1 | 6.92 |
| CHEMBL598845 | — | — | 1 | 6.62 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.42 |
| CHEMBL210955 | — | — | 1 | 6.42 |
| CHEMBL211026 | — | — | 1 | 6.32 |
| CHEMBL606400 | — | — | 1 | 6.21 |
| CHEMBL598437 | — | — | 1 | 6.05 |
| CHEMBL609043 | — | — | 1 | 5.91 |
| CHEMBL599046 | — | — | 1 | 5.82 |
| CHEMBL605323 | — | — | 1 | 5.56 |
| CHEMBL604916 | — | — | 1 | 5.50 |
| CHEMBL597006 | — | — | 1 | 5.38 |
| CHEMBL598222 | — | — | 1 | 5.37 |
| CHEMBL597412 | — | — | 1 | 5.10 |
| CHEMBL597007 | — | — | 1 | - |
| CHEMBL596803 | — | — | 1 | - |
| CHEMBL592853 | — | — | 1 | - |
| CHEMBL597411 | — | — | 1 | - |
| CHEMBL599045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL210405 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL599658 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL597601 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL437490 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL598845 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL42 | CLOZAPINE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL210955 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL211026 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL606400 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL598437 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL609043 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL599046 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL605323 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL604916 | — | Ki | = | 3130.0 | nM | 5.50 |
| CHEMBL597006 | — | Ki | = | 4210.0 | nM | 5.38 |
| CHEMBL598222 | — | Ki | = | 4250.0 | nM | 5.37 |
| CHEMBL597412 | — | Ki | = | 7980.0 | nM | 5.10 |
| CHEMBL597007 | — | Ki | > | 13310.0 | nM | - |
| CHEMBL596803 | — | Ki | > | 13310.0 | nM | - |
| CHEMBL592853 | — | Ki | > | 13310.0 | nM | - |
| CHEMBL597411 | — | Ki | > | 4440.0 | nM | - |
| CHEMBL599045 | — | Ki | > | 4440.0 | nM | - |