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Compound Detail

CHEMBL609043

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Clc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)nn2)cc1

Basic Information

ChEMBL ID CHEMBL609043
Phase Preclinical
Structure Type MOL
InChI Key WFCBAWWBMPFNRM-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

353.9
MW (Da)
3.24
ALogP
5
HBA
0
HBD
37.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H20ClN5
MW 353.86
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -2.22

Activity Summary

Ki 6 meas. best 7.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 2A
CHEMBL322
Ki 7.96 6.46 11.0 2
Unchecked
CHEMBL612545
Ki 6.02 6.02 950.0 2
5-hydroxytryptamine receptor 1A
CHEMBL273
Ki 5.92 5.915 1200.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20153652 10.1016/j.bmc.2010.01.040 Unchecked 4
20153652 10.1016/j.bmc.2010.01.040 5-hydroxytryptamine receptor 1A 1
20153652 10.1016/j.bmc.2010.01.040 5-hydroxytryptamine receptor 2A 1
20363131 10.1016/j.bmcl.2010.03.034 Unchecked 1
20363131 10.1016/j.bmcl.2010.03.034 5-hydroxytryptamine receptor 1A 1
20363131 10.1016/j.bmcl.2010.03.034 5-hydroxytryptamine receptor 2A 1

Data from ChEMBL 36 via Core Engine