Assay Detail
Binding
CHEMBL1067993
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Inhibition of recombinant GST-fused c-Met expressed in baculovirus infected high five cells by DELFIA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.68 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464510 | — | — | 1 | 7.52 |
| CHEMBL465130 | — | — | 1 | 7.40 |
| CHEMBL602704 | — | — | 1 | 7.05 |
| CHEMBL602703 | — | — | 1 | 6.92 |
| CHEMBL602905 | — | — | 1 | 6.75 |
| CHEMBL600603 | — | — | 1 | 6.17 |
| CHEMBL600632 | — | — | 1 | 6.16 |
| CHEMBL591924 | — | — | 1 | 6.08 |
| CHEMBL600604 | — | — | 1 | 6.04 |
| CHEMBL600398 | — | — | 1 | - |
| CHEMBL603082 | — | — | 1 | - |
| CHEMBL612137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464510 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL465130 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL602704 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL602703 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL602905 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL600603 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL600632 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL591924 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL600604 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL600398 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL603082 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL612137 | — | IC50 | > | 5000.0 | nM | - |