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Assay Detail

CHEMBL1068352

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IR by ELISA
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Insulin receptor (CHEMBL1981)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.
Liu X, Xie H, Luo C, Tong L, Wang Y, Peng T, Ding J, Jiang H, Li H.
J Med Chem (2010) 53 : 2661 -2665
PubMed 20178321 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 4.60 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL604159 1 6.04
CHEMBL243946 1 4.71
CHEMBL590023 1 4.56
CHEMBL591252 1 4.55
CHEMBL591702 1 4.44
CHEMBL604254 1 4.24
CHEMBL591504 1 4.18
CHEMBL226813 1 4.10
CHEMBL602518 1 -
CHEMBL602643 1 -
CHEMBL601199 1 -
CHEMBL592665 1 -
CHEMBL592666 1 -
CHEMBL602738 1 -
CHEMBL601494 1 -
CHEMBL591022 1 -
CHEMBL591471 1 -
CHEMBL493742 1 -
CHEMBL591704 1 -
CHEMBL590022 1 -
CHEMBL602919 1 -
CHEMBL599645 1 -
CHEMBL591021 1 -
CHEMBL591014 1 -
CHEMBL589744 1 -
CHEMBL231450 1 -
CHEMBL599975 1 -
CHEMBL589531 1 -
CHEMBL589529 1 -
CHEMBL591020 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL604159 IC50 = 905.0 nM 6.04
CHEMBL243946 IC50 = 19500.0 nM 4.71
CHEMBL590023 IC50 = 27300.0 nM 4.56
CHEMBL591252 IC50 = 28000.0 nM 4.55
CHEMBL591702 IC50 = 36300.0 nM 4.44
CHEMBL604254 IC50 = 57600.0 nM 4.24
CHEMBL591504 IC50 = 65300.0 nM 4.18
CHEMBL226813 IC50 = 79500.0 nM 4.10
CHEMBL591022 IC50 > 100000.0 nM -
CHEMBL599974 IC50 - -
CHEMBL591471 IC50 - -
CHEMBL493742 IC50 > 100000.0 nM -
CHEMBL591704 IC50 - -
CHEMBL602643 IC50 > 100000.0 nM -
CHEMBL601739 IC50 > 100000.0 nM -
CHEMBL591703 IC50 > 100000.0 nM -
CHEMBL602749 IC50 > 100000.0 nM -
CHEMBL589530 IC50 > 100000.0 nM -
CHEMBL590285 IC50 - -
CHEMBL602315 IC50 - -
CHEMBL590521 IC50 - -
CHEMBL589064 IC50 - -
CHEMBL589065 IC50 > 100000.0 nM -
CHEMBL589499 IC50 > 100000.0 nM -
CHEMBL599645 IC50 > 100000.0 nM -
CHEMBL591020 IC50 - -
CHEMBL589529 IC50 - -
CHEMBL589531 IC50 > 100000.0 nM -
CHEMBL599975 IC50 - -
CHEMBL231450 IC50 > 100000.0 nM -
CHEMBL589744 IC50 > 100000.0 nM -
CHEMBL591014 IC50 - -
CHEMBL591021 IC50 > 100000.0 nM -
CHEMBL601494 IC50 - -
CHEMBL602919 IC50 > 100000.0 nM -
CHEMBL590022 IC50 > 100000.0 nM -
CHEMBL602518 IC50 > 100000.0 nM -
CHEMBL601199 IC50 > 100000.0 nM -
CHEMBL592665 IC50 > 100000.0 nM -
CHEMBL592666 IC50 > 100000.0 nM -
CHEMBL602738 IC50 > 100000.0 nM -