Compound Detail
CHEMBL591702
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL591702 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JXQAMMMVMMJMHJ-GHXNOFRVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
316.3
MW (Da)
3.18
ALogP
6
HBA
1
HBD
102.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 5.77 | 5.77 | 1710.0 | 1 |
| Insulin receptor CHEMBL1981 | IC50 | 4.44 | 4.44 | 36300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 1710.0 | nM | 5.77 | Inhibition of IGF1R by ELISA | 20178321 |
| Insulin receptor | IC50 | = | 36300.0 | nM | 4.44 | Inhibition of IR by ELISA | 20178321 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20178321 | 10.1021/jm901798e | Insulin-like growth factor 1 receptor | 1 |
| 20178321 | 10.1021/jm901798e | Insulin receptor | 1 |
| 20178321 | 10.1021/jm901798e | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine