Compound Detail
CHEMBL604159
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Basic Information
| ChEMBL ID | CHEMBL604159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SXAUTKUIIXFACR-SDQBBNPISA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
331.3
MW (Da)
2.67
ALogP
6
HBA
3
HBD
116.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
| Insulin receptor CHEMBL1981 | IC50 | 6.04 | 6.04 | 905.0 | 1 |
| MCF7 CHEMBL387 | IC50 | 4.09 | 4.09 | 81300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 250.0 | nM | 6.6 | Inhibition of IGF1R by ELISA | 20178321 |
| Insulin receptor | IC50 | = | 905.0 | nM | 6.04 | Inhibition of IR by ELISA | 20178321 |
| MCF7 | IC50 | = | 81300.0 | nM | 4.09 | Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay | 20178321 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20178321 | 10.1021/jm901798e | Insulin-like growth factor 1 receptor | 1 |
| 20178321 | 10.1021/jm901798e | Insulin receptor | 1 |
| 20178321 | 10.1021/jm901798e | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine