Assay Detail
ADMET
CHEMBL1068899
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Inhibition of human CYP3A4 by fluorescence assay
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.46 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590472 | — | — | 1 | 5.52 |
| CHEMBL598644 | — | — | 1 | 5.40 |
| CHEMBL2021582 | — | — | 1 | - |
| CHEMBL598215 | — | — | 1 | - |
| CHEMBL605209 | — | — | 1 | - |
| CHEMBL2021577 | — | — | 1 | - |
| CHEMBL608151 | — | — | 2 | - |
| CHEMBL596809 | — | — | 1 | - |
| CHEMBL610795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590472 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL598644 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2021582 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL598215 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL605209 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL2021577 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL608151 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL608151 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL596809 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL610795 | — | IC50 | > | 10000.0 | nM | - |