Assay Detail
Functional
CHEMBL1068973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.65 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 6.30 |
| CHEMBL384527 | — | — | 1 | 5.00 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | - |
| CHEMBL601438 | — | — | 1 | - |
| CHEMBL603083 | — | — | 1 | - |
| CHEMBL602071 | — | — | 1 | - |
| CHEMBL590738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL384527 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | - | — | - | |
| CHEMBL601438 | — | EC50 | - | — | - | |
| CHEMBL603083 | — | EC50 | - | — | - | |
| CHEMBL602071 | — | EC50 | - | — | - | |
| CHEMBL590738 | — | EC50 | >= | 20000.0 | nM | - |