Assay Detail
Toxicity
CHEMBL1069449
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Toxicity in MDCK cells by MTT method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.83 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.02 |
| CHEMBL592496 | — | — | 1 | 4.63 |
| CHEMBL592000 | — | — | 1 | - |
| CHEMBL592637 | — | — | 1 | - |
| CHEMBL591065 | — | — | 1 | - |
| CHEMBL592485 | — | — | 1 | - |
| CHEMBL590790 | — | — | 1 | - |
| CHEMBL592638 | — | — | 1 | - |
| CHEMBL70927 | DEFERIPRONE | 4.0 | 1 | - |
| CHEMBL550348 | DEFERASIROX | 4.0 | 1 | - |
| CHEMBL385064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 9490.0 | nM | 5.02 |
| CHEMBL592496 | — | IC50 | = | 23410.0 | nM | 4.63 |
| CHEMBL592000 | — | IC50 | = | 118860.0 | nM | - |
| CHEMBL592637 | — | IC50 | = | 163370.0 | nM | - |
| CHEMBL591065 | — | IC50 | = | 225560.0 | nM | - |
| CHEMBL592485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL590790 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL592638 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL70927 | DEFERIPRONE | IC50 | - | — | - | |
| CHEMBL550348 | DEFERASIROX | IC50 | - | — | - | |
| CHEMBL385064 | — | IC50 | - | — | - |