Assay Detail
Binding
CHEMBL1069954
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.26 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595194 | — | — | 1 | 9.15 |
| CHEMBL609306 | — | — | 1 | 9.00 |
| CHEMBL593545 | — | — | 1 | 8.70 |
| CHEMBL595195 | — | — | 1 | 8.42 |
| CHEMBL594717 | — | — | 1 | 8.36 |
| CHEMBL594469 | — | — | 1 | 7.82 |
| CHEMBL595645 | — | — | 1 | 7.80 |
| CHEMBL593547 | — | — | 1 | 7.68 |
| CHEMBL595553 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595194 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL609306 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL593545 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL595195 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL594717 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL594469 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL595645 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL593547 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL595553 | — | Ki | = | 41.0 | nM | 7.39 |