Assay Detail
Binding
CHEMBL1070909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) (CHEMBL2221348) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel KCNQ2/Q3 agonists as potential therapeutics for epilepsy and neuropathic pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.83 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598553 | — | — | 1 | 7.68 |
| CHEMBL592297 | — | — | 1 | 7.64 |
| CHEMBL599164 | — | — | 1 | 7.60 |
| CHEMBL598126 | — | — | 1 | 7.57 |
| CHEMBL604937 | — | — | 1 | 7.55 |
| CHEMBL599374 | — | — | 1 | 7.55 |
| CHEMBL589898 | — | — | 1 | 7.54 |
| CHEMBL591302 | — | — | 1 | 7.36 |
| CHEMBL609624 | — | — | 1 | 7.36 |
| CHEMBL599376 | — | — | 1 | 7.31 |
| CHEMBL599781 | — | — | 1 | 7.28 |
| CHEMBL599375 | — | — | 1 | 7.21 |
| CHEMBL596909 | — | — | 1 | 7.04 |
| CHEMBL602305 | — | — | 1 | 7.02 |
| CHEMBL591203 | — | — | 1 | 7.01 |
| CHEMBL589667 | — | — | 1 | 7.00 |
| CHEMBL599365 | — | — | 1 | 6.80 |
| CHEMBL603662 | — | — | 1 | 6.80 |
| CHEMBL597341 | — | — | 1 | 6.66 |
| CHEMBL592146 | — | — | 1 | 6.58 |
| CHEMBL603661 | — | — | 1 | 6.42 |
| CHEMBL602304 | — | — | 1 | 6.30 |
| CHEMBL597329 | — | — | 1 | 6.24 |
| CHEMBL608156 | — | — | 1 | 6.15 |
| CHEMBL603667 | — | — | 1 | 5.68 |
| CHEMBL603874 | — | — | 1 | 5.57 |
| CHEMBL597342 | — | — | 1 | 5.25 |
| CHEMBL597544 | — | — | 1 | 5.17 |
| CHEMBL591677 | — | — | 1 | - |
| CHEMBL597330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598553 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL592297 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL599164 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL598126 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL604937 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL599374 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL589898 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL591302 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL609624 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL599376 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL599781 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL599375 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL596909 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL602305 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL591203 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL589667 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL599365 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL603662 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL597341 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL592146 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL603661 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL602304 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL597329 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL608156 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL603667 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL603874 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL597342 | — | EC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL597544 | — | EC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL591677 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL597330 | — | EC50 | > | 10000.0 | nM | - |