Compound Detail
CHEMBL604937
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Basic Information
| ChEMBL ID | CHEMBL604937 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCWOPFQCJRRYMU-PYCFMQQDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
359.5
MW (Da)
3.53
ALogP
4
HBA
1
HBD
46.4
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) CHEMBL2221348 | EC50 | 7.55 | 7.55 | 28.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) | EC50 | = | 28.0 | nM | 7.55 | Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay | 20020710 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20020710 | 10.1021/jm901497b | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) | 1 |
| 20020710 | 10.1021/jm901497b | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine