Assay Detail
Binding
CHEMBL1072348
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Binding affinity to VEGF by surface plasmon-based solution affinity assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor A, long form (CHEMBL1783) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 8.34 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604368 | — | — | 1 | 9.21 |
| CHEMBL590011 | — | — | 1 | 9.15 |
| CHEMBL604570 | — | — | 1 | 9.10 |
| CHEMBL604568 | — | — | 1 | 8.85 |
| CHEMBL604366 | — | — | 1 | 8.82 |
| CHEMBL603122 | — | — | 1 | 8.74 |
| CHEMBL4297162 | MUPARFOSTAT SODIUM | -1.0 | 1 | 8.66 |
| CHEMBL590013 | — | — | 1 | 8.29 |
| CHEMBL602307 | — | — | 1 | 8.15 |
| CHEMBL590012 | — | — | 1 | 8.05 |
| CHEMBL602114 | — | — | 1 | 7.98 |
| CHEMBL604367 | — | — | 1 | 7.92 |
| CHEMBL590010 | — | — | 1 | 7.92 |
| CHEMBL2029015 | — | — | 1 | 7.91 |
| CHEMBL602113 | — | — | 1 | 7.75 |
| CHEMBL589773 | — | — | 1 | 7.68 |
| CHEMBL604569 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604368 | — | Kd | = | 0.62 | nM | 9.21 |
| CHEMBL590011 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL604570 | — | Kd | = | 0.79 | nM | 9.10 |
| CHEMBL604568 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL604366 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL603122 | — | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL4297162 | MUPARFOSTAT SODIUM | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL590013 | — | Kd | = | 5.1 | nM | 8.29 |
| CHEMBL602307 | — | Kd | = | 7.1 | nM | 8.15 |
| CHEMBL590012 | — | Kd | = | 8.9 | nM | 8.05 |
| CHEMBL602114 | — | Kd | = | 10.4 | nM | 7.98 |
| CHEMBL604367 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL590010 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL2029015 | — | Kd | = | 12.2 | nM | 7.91 |
| CHEMBL602113 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL589773 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL604569 | — | Kd | = | 25.0 | nM | 7.60 |