Compound Detail
CHEMBL602113
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CCCCCCCCO[C@H]1O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](OS(=O)(=O)[O-])[C@@H]1O[C@H]1O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](O[C@H]2O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](O[C@H]3O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](OS(=O)(=O)[O-])[C@@H]3OS(=O)(=O)[O-])[C@@H]2OS(=O)(=O)[O-])[C@@H]1OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Basic Information
| ChEMBL ID | CHEMBL602113 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MUJAPTQNMDMUNI-IBJNBQBESA-A |
| Parent Compound | CHEMBL1615736 |
| Active Moiety | CHEMBL1615736 |
4
Targets
4
Activities
1
Assay Types
5
PK Parameters
9
Publications
0
Known Names
Molecular Properties
1819.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form CHEMBL1783 | Kd | 7.75 | 7.75 | 18.0 | 1 |
| Fibroblast growth factor 1 CHEMBL2120 | Kd | 6.93 | 6.93 | 118.0 | 1 |
| Fibroblast growth factor 2 CHEMBL3107 | Kd | 6.8 | 6.8 | 160.0 | 1 |
| Heparanase CHEMBL3921 | Kd | 6.48 | 6.48 | 330.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.2 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 67.0 | % | Rattus norvegicus |
| T1/2 | 1.7 | hr | Rattus norvegicus |
| T1/2 | 1.7 | hr | Rattus norvegicus |
| Vd | 0.026 | L.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form | Kd | = | 18.0 | nM | 7.75 | Binding affinity to VEGF by surface plasmon-based solution affinity assay | 20128596 |
| Fibroblast growth factor 1 | Kd | = | 118.0 | nM | 6.93 | Binding affinity to FGF1 by surface plasmon-based solution affinity assay | 20128596 |
| Fibroblast growth factor 2 | Kd | = | 160.0 | nM | 6.8 | Binding affinity to FGF2 by surface plasmon-based solution affinity assay | 20128596 |
| Heparanase | Kd | = | 330.0 | nM | 6.48 | Inhibition of human recombinant heparanase | 20128596 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20128596 | 10.1021/jm901449m | Rattus norvegicus | 6 |
| 20128596 | 10.1021/jm901449m | Plasma | 2 |
| 20128596 | 10.1021/jm901449m | B16 | 2 |
| 20128596 | 10.1021/jm901449m | Heparanase | 1 |
| 20128596 | 10.1021/jm901449m | Fibroblast growth factor 1 | 1 |
| 20128596 | 10.1021/jm901449m | Fibroblast growth factor 2 | 1 |
| 20128596 | 10.1021/jm901449m | Vascular endothelial growth factor A, long form | 1 |
| 20128596 | 10.1021/jm901449m | HUVEC | 1 |
| 20128596 | 10.1021/jm901449m | ADMET | 1 |
Data from ChEMBL 36 via Core Engine