Compound Detail
CHEMBL604570
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=S(=O)([O-])OC[C@H]1O[C@H](OCCCCCCCCCCCCn2cc(-c3cccc4ccccc34)nn2)[C@@H](O[C@H]2O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](O[C@H]3O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](O[C@H]4O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](O[C@H]5O[C@H](COS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@H](OS(=O)(=O)[O-])[C@@H]5OS(=O)(=O)[O-])[C@@H]4OS(=O)(=O)[O-])[C@@H]3OS(=O)(=O)[O-])[C@@H]2OS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])[C@@H]1OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Basic Information
| ChEMBL ID | CHEMBL604570 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZYJPBJOSIZWBRW-TWXKLBOZSA-A |
| Parent Compound | CHEMBL1615730 |
| Active Moiety | CHEMBL1615730 |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
2471.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form CHEMBL1783 | Kd | 9.1 | 9.1 | 0.8 | 1 |
| Fibroblast growth factor 2 CHEMBL3107 | Kd | 7.14 | 7.14 | 73.0 | 1 |
| Fibroblast growth factor 1 CHEMBL2120 | Kd | 6.72 | 6.72 | 190.0 | 1 |
| Heparanase CHEMBL3921 | Kd | 6.57 | 6.57 | 270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form | Kd | = | 0.79 | nM | 9.1 | Binding affinity to VEGF by surface plasmon-based solution affinity assay | 20128596 |
| Fibroblast growth factor 2 | Kd | = | 73.0 | nM | 7.14 | Binding affinity to FGF2 by surface plasmon-based solution affinity assay | 20128596 |
| Fibroblast growth factor 1 | Kd | = | 190.0 | nM | 6.72 | Binding affinity to FGF1 by surface plasmon-based solution affinity assay | 20128596 |
| Heparanase | Kd | = | 270.0 | nM | 6.57 | Inhibition of human recombinant heparanase | 20128596 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20128596 | 10.1021/jm901449m | Plasma | 2 |
| 20128596 | 10.1021/jm901449m | Heparanase | 1 |
| 20128596 | 10.1021/jm901449m | Fibroblast growth factor 1 | 1 |
| 20128596 | 10.1021/jm901449m | Fibroblast growth factor 2 | 1 |
| 20128596 | 10.1021/jm901449m | Vascular endothelial growth factor A, long form | 1 |
| 20128596 | 10.1021/jm901449m | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine