Assay Detail
Binding
CHEMBL1072382
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Inhibition of serotonin uptake at human SERT expressed in human JAR cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JAR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.42 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598168 | — | — | 1 | 8.55 |
| CHEMBL597968 | — | — | 1 | 8.26 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.03 |
| CHEMBL610514 | — | — | 1 | 7.68 |
| CHEMBL599608 | — | — | 1 | 7.54 |
| CHEMBL605213 | — | — | 1 | 7.08 |
| CHEMBL467323 | — | — | 1 | 6.95 |
| CHEMBL599813 | — | — | 1 | 6.81 |
| CHEMBL592167 | — | — | 1 | 6.71 |
| CHEMBL14370 | REBOXETINE | 4.0 | 1 | 6.62 |
| CHEMBL600674 | — | — | 1 | 6.55 |
| CHEMBL599609 | — | — | 1 | 6.48 |
| CHEMBL603109 | — | — | 1 | 6.44 |
| CHEMBL597967 | — | — | 1 | 6.30 |
| CHEMBL601879 | — | — | 1 | 6.09 |
| CHEMBL591928 | — | — | 1 | 5.96 |
| CHEMBL606174 | — | — | 1 | 5.95 |
| CHEMBL598614 | — | — | 1 | 5.79 |
| CHEMBL605990 | — | — | 1 | 5.71 |
| CHEMBL469150 | — | — | 1 | 5.58 |
| CHEMBL600220 | — | — | 1 | 5.54 |
| CHEMBL601880 | — | — | 1 | 5.34 |
| CHEMBL602550 | — | — | 1 | 5.31 |
| CHEMBL603920 | — | — | 1 | 5.30 |
| CHEMBL600424 | — | — | 1 | 5.28 |
| CHEMBL603495 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598168 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL597968 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL610514 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL599608 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL605213 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL467323 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL599813 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL592167 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL14370 | REBOXETINE | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL600674 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL599609 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL603109 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL597967 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL601879 | — | IC50 | = | 813.0 | nM | 6.09 |
| CHEMBL591928 | — | IC50 | = | 1099.0 | nM | 5.96 |
| CHEMBL606174 | — | IC50 | = | 1123.0 | nM | 5.95 |
| CHEMBL598614 | — | IC50 | = | 1614.0 | nM | 5.79 |
| CHEMBL605990 | — | IC50 | = | 1969.0 | nM | 5.71 |
| CHEMBL469150 | — | IC50 | = | 2607.0 | nM | 5.58 |
| CHEMBL600220 | — | IC50 | = | 2871.0 | nM | 5.54 |
| CHEMBL601880 | — | IC50 | = | 4519.0 | nM | 5.34 |
| CHEMBL602550 | — | IC50 | = | 4917.0 | nM | 5.31 |
| CHEMBL603920 | — | IC50 | = | 4992.0 | nM | 5.30 |
| CHEMBL600424 | — | IC50 | = | 5293.0 | nM | 5.28 |
| CHEMBL603495 | — | IC50 | = | 8971.0 | nM | 5.05 |