Assay Detail
Binding
CHEMBL1073246
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Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells by liquid scintillation counting
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL2489) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.72 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595632 | — | — | 1 | 6.17 |
| CHEMBL593260 | — | — | 1 | 6.04 |
| CHEMBL605833 | — | — | 1 | 5.96 |
| CHEMBL595157 | — | — | 1 | 5.85 |
| CHEMBL603653 | — | — | 1 | 5.68 |
| CHEMBL594423 | — | — | 1 | 5.66 |
| CHEMBL596515 | — | — | 1 | 5.66 |
| CHEMBL594365 | — | — | 1 | 5.66 |
| CHEMBL604897 | — | — | 1 | 5.64 |
| CHEMBL593764 | — | — | 1 | 5.58 |
| CHEMBL593041 | — | — | 1 | 5.58 |
| CHEMBL595159 | — | — | 1 | 5.54 |
| CHEMBL594210 | — | — | 1 | 5.37 |
| CHEMBL593526 | — | — | 1 | - |
| CHEMBL596499 | — | — | 1 | - |
| CHEMBL603227 | — | — | 1 | - |
| CHEMBL603625 | — | — | 1 | - |
| CHEMBL603633 | — | — | 1 | - |
| CHEMBL595830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595632 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL593260 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL605833 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL595157 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL603653 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL594423 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL596515 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL594365 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL604897 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL593764 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL593041 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL595159 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL594210 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL593526 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL596499 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL603227 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL603625 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL603633 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL595830 | — | Ki | > | 10000.0 | nM | - |