Compound Detail
CHEMBL593260
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Basic Information
| ChEMBL ID | CHEMBL593260 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQMZJMKFBPBGJZ-VQHVLOKHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
426.5
MW (Da)
4.98
ALogP
5
HBA
2
HBD
85.2
PSA (Ų)
0.61
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype CHEMBL2489 | Ki | 6.04 | 6.04 | 920.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL2488 | Ki | 5.17 | 5.17 | 6800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype | Ki | = | 920.0 | nM | 6.04 | Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells by liqui... | 19700331 |
| Prostaglandin E2 receptor EP2 subtype | Ki | = | 6800.0 | nM | 5.17 | Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liqui... | 19700331 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19700331 | 10.1016/j.bmc.2009.08.007 | Prostaglandin E2 receptor EP3 subtype | 2 |
| 19700331 | 10.1016/j.bmc.2009.08.007 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 19700331 | 10.1016/j.bmc.2009.08.007 | Prostaglandin E2 receptor EP2 subtype | 1 |
| 19700331 | 10.1016/j.bmc.2009.08.007 | Prostaglandin E2 receptor EP1 subtype | 1 |
Data from ChEMBL 36 via Core Engine