Assay Detail
Binding
CHEMBL1074040
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Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cells
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.30 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552167 | — | — | 1 | 9.89 |
| CHEMBL196468 | — | — | 1 | 9.44 |
| CHEMBL609908 | — | — | 3 | 9.38 |
| CHEMBL234706 | — | — | 1 | 9.14 |
| CHEMBL180630 | — | — | 1 | 8.70 |
| CHEMBL599684 | — | — | 1 | 8.68 |
| CHEMBL590487 | — | — | 1 | 8.60 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.60 |
| CHEMBL606244 | — | — | 1 | 8.41 |
| CHEMBL592776 | — | — | 1 | 8.40 |
| CHEMBL598042 | — | — | 1 | 8.24 |
| CHEMBL600890 | — | — | 1 | 8.15 |
| CHEMBL605535 | — | — | 1 | 8.12 |
| CHEMBL600263 | — | — | 1 | 8.09 |
| CHEMBL601503 | — | — | 1 | 7.77 |
| CHEMBL596615 | — | — | 1 | 7.77 |
| CHEMBL596613 | — | — | 1 | 7.75 |
| CHEMBL591829 | — | — | 1 | 7.34 |
| CHEMBL596614 | — | — | 1 | 7.12 |
| CHEMBL591830 | — | — | 1 | 7.10 |
| CHEMBL597031 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552167 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL196468 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL609908 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL234706 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL609908 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL180630 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL599684 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL590487 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL606244 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL592776 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL609908 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL598042 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL600890 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL605535 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL600263 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL601503 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL596615 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL596613 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL591829 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL596614 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL591830 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL597031 | — | IC50 | = | 120.0 | nM | 6.92 |