Assay Detail
Binding
CHEMBL1074487
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Inhibition of PLAP by analogous luminescence assay
39
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phospholipase A-2-activating protein (CHEMBL6114) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of selective inhibitors of placental alkaline phosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.30 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607856 | — | — | 2 | 6.10 |
| CHEMBL608723 | — | — | 1 | 6.10 |
| CHEMBL597055 | — | — | 2 | 5.92 |
| CHEMBL254255 | — | — | 1 | 5.70 |
| CHEMBL349641 | — | — | 1 | 5.68 |
| CHEMBL598663 | — | — | 1 | 5.66 |
| CHEMBL592869 | — | — | 1 | 5.60 |
| CHEMBL610781 | — | — | 1 | 5.57 |
| CHEMBL610508 | — | — | 1 | 5.52 |
| CHEMBL589756 | — | — | 2 | 5.48 |
| CHEMBL597109 | — | — | 1 | 5.31 |
| CHEMBL597027 | — | — | 1 | 5.24 |
| CHEMBL602242 | — | — | 1 | 5.24 |
| CHEMBL609899 | — | — | 1 | 5.17 |
| CHEMBL597837 | — | — | 1 | 5.04 |
| CHEMBL602448 | — | — | 1 | 4.87 |
| CHEMBL597028 | — | — | 1 | 4.80 |
| CHEMBL608722 | — | — | 1 | 4.76 |
| CHEMBL598662 | — | — | 1 | 4.41 |
| CHEMBL596813 | — | — | 1 | 4.29 |
| CHEMBL358546 | — | — | 1 | - |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 1 | - |
| CHEMBL291962 | LEUCINE | 3.0 | 1 | - |
| CHEMBL589752 | — | — | 1 | - |
| CHEMBL598548 | LEUCINE AMIDE | — | 1 | - |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | - |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
| CHEMBL301523 | PHENYLALANINE | 3.0 | 1 | - |
| CHEMBL599359 | — | — | 1 | - |
| CHEMBL599678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608723 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL607856 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL597055 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL254255 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL349641 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL598663 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL592869 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL610781 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL610508 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL589756 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL607856 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL597109 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL597027 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL602242 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL597055 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL609899 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL597837 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL602448 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL589756 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL597028 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL608722 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL598662 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL596813 | — | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL54976 | TRYPTOPHAN | IC50 | > | 5000.0 | nM | - |
| CHEMBL291962 | LEUCINE | IC50 | > | 5000.0 | nM | - |
| CHEMBL589752 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL598548 | LEUCINE AMIDE | IC50 | > | 5000.0 | nM | - |
| CHEMBL1454 | LEVAMISOLE | IC50 | > | 5000.0 | nM | - |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | > | 5000.0 | nM | - |
| CHEMBL301523 | PHENYLALANINE | IC50 | > | 5000.0 | nM | - |
| CHEMBL597421 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL599967 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL596810 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL599359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358546 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL599678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL599476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL596812 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL596811 | — | IC50 | > | 100000.0 | nM | - |