Assay Detail
Binding
CHEMBL1100233
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Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.38 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080925 | — | — | 1 | 9.68 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 9.64 |
| CHEMBL1076579 | — | — | 1 | 9.62 |
| CHEMBL1076572 | — | — | 1 | 9.02 |
| CHEMBL1076573 | — | — | 1 | 8.92 |
| CHEMBL1076578 | — | — | 1 | 8.62 |
| CHEMBL1076576 | — | — | 1 | 8.49 |
| CHEMBL1076577 | — | — | 1 | 8.32 |
| CHEMBL1081608 | — | — | 1 | 8.19 |
| CHEMBL1075629 | — | — | 1 | 8.15 |
| CHEMBL1081084 | — | — | 1 | 8.14 |
| CHEMBL1081250 | — | — | 1 | 8.13 |
| CHEMBL1076575 | — | — | 1 | 7.92 |
| CHEMBL1076574 | — | — | 1 | 7.77 |
| CHEMBL348023 | — | — | 1 | 7.54 |
| CHEMBL151872 | — | — | 1 | 7.18 |
| CHEMBL1081093 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080925 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1076579 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1076572 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL1076573 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1076578 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1076576 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1076577 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL1081608 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1075629 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL1081084 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1081250 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1076575 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1076574 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL348023 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL151872 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL1081093 | — | Ki | = | 70.0 | nM | 7.16 |