Assay Detail
ADMET
CHEMBL1100431
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Inhibition of CYP3A4 using diethoxyfluorescein substrate
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.30 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076245 | — | — | 1 | 6.00 |
| CHEMBL1079437 | — | — | 1 | 5.89 |
| CHEMBL1079957 | — | — | 1 | 5.80 |
| CHEMBL1080088 | — | — | 1 | 5.62 |
| CHEMBL1079958 | — | — | 1 | 5.54 |
| CHEMBL1080472 | — | — | 1 | 5.52 |
| CHEMBL1076192 | — | — | 1 | 5.51 |
| CHEMBL238146 | — | — | 1 | 5.42 |
| CHEMBL1080717 | — | — | 1 | 5.33 |
| CHEMBL1076536 | — | — | 1 | 5.26 |
| CHEMBL1080803 | — | — | 1 | 5.25 |
| CHEMBL1080982 | — | — | 1 | 5.22 |
| CHEMBL1087758 | — | — | 1 | 5.22 |
| CHEMBL1080473 | — | — | 1 | 5.11 |
| CHEMBL1081504 | — | — | 1 | 5.06 |
| CHEMBL1076210 | — | — | 1 | 5.05 |
| CHEMBL47529 | — | — | 1 | 5.05 |
| CHEMBL497011 | LINAPRAZAN | 2.0 | 1 | 5.05 |
| CHEMBL1081870 | — | — | 1 | 4.92 |
| CHEMBL1081505 | — | — | 1 | 4.89 |
| CHEMBL1079436 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076245 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1079437 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1079957 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1080088 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1079958 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1080472 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1076192 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL238146 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1080717 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1076536 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1080803 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1080982 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1087758 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1080473 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1081504 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1076210 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL47529 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL497011 | LINAPRAZAN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1081870 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1081505 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1079436 | — | IC50 | = | 22000.0 | nM | 4.66 |