Assay Detail
Binding
CHEMBL1101481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serotonin uptake at human SERT expressed in human JAR
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.78 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083211 | — | — | 1 | 6.96 |
| CHEMBL1204413 | — | — | 1 | 6.62 |
| CHEMBL1204414 | — | — | 1 | 6.47 |
| CHEMBL1204415 | — | — | 1 | 6.22 |
| CHEMBL1096001 | — | — | 1 | 6.14 |
| CHEMBL1083210 | — | — | 1 | 5.82 |
| CHEMBL1084933 | — | — | 1 | 5.70 |
| CHEMBL1204410 | — | — | 1 | 5.60 |
| CHEMBL1087924 | — | — | 1 | 5.26 |
| CHEMBL1086398 | — | — | 1 | 5.22 |
| CHEMBL1077209 | — | — | 1 | 5.16 |
| CHEMBL1204412 | — | — | 1 | 5.10 |
| CHEMBL1084934 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083211 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1204413 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1204414 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1204415 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1096001 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1083210 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1084933 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1204410 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1087924 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1086398 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1077209 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1204412 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1084934 | — | IC50 | = | 13300.0 | nM | 4.88 |