Assay Detail
ADMET
CHEMBL1102238
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Inhibition of CYP3A4 after 20 mins by BFC fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.71 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077339 | — | — | 1 | 6.30 |
| CHEMBL401930 | — | — | 1 | 6.30 |
| CHEMBL1077343 | — | — | 1 | 6.16 |
| CHEMBL1078891 | — | — | 1 | 6.10 |
| CHEMBL1077340 | — | — | 1 | 6.00 |
| CHEMBL482126 | — | — | 1 | 5.77 |
| CHEMBL256072 | — | — | 1 | 5.72 |
| CHEMBL401766 | — | — | 1 | 5.68 |
| CHEMBL1097357 | — | — | 1 | 5.52 |
| CHEMBL1097358 | — | — | 1 | 5.46 |
| CHEMBL1077324 | — | — | 1 | 4.80 |
| CHEMBL1078892 | — | — | 1 | 4.75 |
| CHEMBL480966 | — | — | 1 | - |
| CHEMBL1077325 | — | — | 1 | - |
| CHEMBL505919 | — | — | 1 | - |
| CHEMBL482101 | — | — | 1 | - |
| CHEMBL1078991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077339 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL401930 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1077343 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1078891 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1077340 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL482126 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL256072 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL401766 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1097357 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1097358 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1077324 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1078892 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL480966 | — | IC50 | = | 700.0 | nM | - |
| CHEMBL1077325 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL505919 | — | IC50 | = | 3500.0 | nM | - |
| CHEMBL482101 | — | IC50 | = | 700.0 | nM | - |
| CHEMBL1078991 | — | IC50 | > | 4400.0 | nM | - |