Assay Detail
Binding
CHEMBL1102464
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Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.97 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1080107 | — | — | 1 | 7.82 |
| CHEMBL1081723 | — | — | 1 | 7.52 |
| CHEMBL1080634 | — | — | 1 | 7.50 |
| CHEMBL1081722 | — | — | 1 | 7.46 |
| CHEMBL1080306 | — | — | 1 | 7.33 |
| CHEMBL1080305 | — | — | 1 | 7.25 |
| CHEMBL1081362 | — | — | 1 | 7.14 |
| CHEMBL1081361 | — | — | 1 | 7.11 |
| CHEMBL1076306 | — | — | 1 | 7.07 |
| CHEMBL1076319 | — | — | 1 | 7.06 |
| CHEMBL190117 | — | — | 1 | 7.05 |
| CHEMBL1081900 | — | — | 1 | 7.00 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 6.96 |
| CHEMBL1079608 | — | — | 1 | 6.96 |
| CHEMBL1079733 | — | — | 1 | 6.92 |
| CHEMBL1080633 | — | — | 1 | 6.91 |
| CHEMBL1082097 | — | — | 1 | 6.90 |
| CHEMBL1079595 | — | — | 1 | 6.85 |
| CHEMBL1076262 | — | — | 1 | 6.83 |
| CHEMBL1081172 | — | — | 1 | 6.71 |
| CHEMBL425194 | — | — | 1 | 6.68 |
| CHEMBL1080304 | — | — | 1 | 6.66 |
| CHEMBL189051 | — | — | 1 | 6.63 |
| CHEMBL1076297 | — | — | 1 | 6.41 |
| CHEMBL1079781 | — | — | 1 | 6.26 |
| CHEMBL1080307 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1080107 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1081723 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1080634 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1081722 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1080306 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1080305 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1081362 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1081361 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1076306 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1076319 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL190117 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1081900 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1405 | ESTRONE | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1079608 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1079733 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL1080633 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1082097 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1079595 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1076262 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1081172 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL425194 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1080304 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL189051 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1076297 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL1079781 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL1080307 | — | IC50 | = | 633.0 | nM | 6.20 |