Assay Detail
Binding
CHEMBL1102908
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Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.61 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.40 |
| CHEMBL75729 | — | — | 1 | 6.77 |
| CHEMBL1081834 | — | — | 1 | 6.75 |
| CHEMBL1081835 | — | — | 1 | 6.35 |
| CHEMBL1080546 | — | — | 1 | 6.01 |
| CHEMBL1080547 | — | — | 1 | 5.80 |
| CHEMBL1081970 | — | — | 1 | 5.72 |
| CHEMBL1081032 | — | — | 1 | 5.60 |
| CHEMBL1081031 | — | — | 1 | 5.25 |
| CHEMBL1081969 | — | — | 1 | 4.96 |
| CHEMBL1080387 | — | — | 1 | 4.82 |
| CHEMBL1081456 | — | — | 1 | 4.48 |
| CHEMBL1081455 | — | — | 1 | 4.36 |
| CHEMBL1081085 | — | — | 1 | 4.32 |
| CHEMBL1080753 | — | — | 1 | - |
| CHEMBL1081457 | — | — | 1 | - |
| CHEMBL1081968 | — | — | 1 | - |
| CHEMBL1081433 | — | — | 1 | - |
| CHEMBL1079797 | — | — | 1 | - |
| CHEMBL1081652 | — | — | 1 | - |
| CHEMBL1081653 | — | — | 1 | - |
| CHEMBL1080386 | PHENETHYLCYMSERINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL75729 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1081834 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1081835 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1080546 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1080547 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1081970 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1081032 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1081031 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1081969 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1080387 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1081456 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1081455 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1081085 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1080753 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1081457 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1081968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1081433 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1079797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1081652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1081653 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1080386 | PHENETHYLCYMSERINE | IC50 | > | 100000.0 | nM | - |