Assay Detail
Binding
CHEMBL1103009
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Inhibition of HSP90-mediated client protein HER2 degradation
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Heat shock protein 90: inhibitors in clinical trials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.15 | 8.15 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.15 |
| CHEMBL339231 | — | — | 1 | 8.15 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 8.15 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.15 |
| CHEMBL467399 | BIIB021 | 2.0 | 1 | 8.15 |
| CHEMBL1082229 | — | — | 1 | - |
| CHEMBL381115 | — | — | 1 | - |
| CHEMBL365159 | — | — | 1 | - |
| CHEMBL377371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL339231 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL560895 | SNX-2112 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL467399 | BIIB021 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1082229 | — | Activity | = | 40.0 | uM | - |
| CHEMBL381115 | — | Activity | = | 30.0 | nM | - |
| CHEMBL365159 | — | Activity | = | 30.0 | nM | - |
| CHEMBL377371 | — | Activity | = | 30.0 | nM | - |