Assay Detail
Binding
CHEMBL1103914
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Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Macrophage-stimulating protein receptor (CHEMBL2689) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a novel series of potent RON receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.95 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095359 | — | — | 1 | 7.52 |
| CHEMBL1095356 | — | — | 1 | 7.52 |
| CHEMBL1095360 | — | — | 1 | 7.40 |
| CHEMBL1094718 | — | — | 1 | 7.30 |
| CHEMBL1095035 | — | — | 1 | 7.22 |
| CHEMBL1095034 | — | — | 1 | 7.22 |
| CHEMBL1087984 | — | — | 1 | 7.10 |
| CHEMBL1095036 | — | — | 1 | 7.10 |
| CHEMBL1095357 | — | — | 1 | 7.05 |
| CHEMBL1095361 | — | — | 1 | 7.05 |
| CHEMBL1095358 | — | — | 1 | 7.00 |
| CHEMBL1086932 | — | — | 1 | 6.82 |
| CHEMBL462232 | — | — | 1 | 6.77 |
| CHEMBL1098158 | — | — | 1 | 6.70 |
| CHEMBL1086675 | — | — | 1 | 6.68 |
| CHEMBL600632 | — | — | 1 | 6.39 |
| CHEMBL1086676 | — | — | 1 | 6.23 |
| CHEMBL602703 | — | — | 1 | 5.99 |
| CHEMBL1098157 | — | — | 1 | - |
| CHEMBL1097824 | — | — | 1 | - |
| CHEMBL1088539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095359 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1095356 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1095360 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1094718 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1095035 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1095034 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1087984 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1095036 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1095357 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1095361 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1095358 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1086932 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL462232 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1098158 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1086675 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL600632 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1086676 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL602703 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1098157 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1097824 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1088539 | — | IC50 | > | 10000.0 | nM | - |