Assay Detail
Functional
CHEMBL1104481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi tulahuen C4 trypomastigotes infected in african green monkey Vero cells assessed as CPRG cleavage after 120 hrs by microplate reader
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 4.90 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090564 | — | — | 1 | 5.85 |
| CHEMBL1090250 | — | — | 1 | 5.41 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.35 |
| CHEMBL1092684 | — | — | 1 | 5.28 |
| CHEMBL1091972 | — | — | 1 | 5.03 |
| CHEMBL1092279 | — | — | 1 | 4.98 |
| CHEMBL1090594 | — | — | 1 | 4.97 |
| CHEMBL1092685 | — | — | 1 | 4.95 |
| CHEMBL1092698 | — | — | 1 | 4.95 |
| CHEMBL1093245 | — | — | 1 | 4.89 |
| CHEMBL1093506 | — | — | 1 | 4.88 |
| CHEMBL1090595 | — | — | 1 | 4.88 |
| CHEMBL1093852 | — | — | 1 | 4.86 |
| CHEMBL1091956 | — | — | 1 | 4.86 |
| CHEMBL1093851 | — | — | 1 | 4.85 |
| CHEMBL1093232 | — | — | 1 | 4.84 |
| CHEMBL1093872 | — | — | 1 | 4.81 |
| CHEMBL1092699 | — | — | 1 | 4.80 |
| CHEMBL1093905 | — | — | 1 | 4.79 |
| CHEMBL1090898 | — | — | 1 | 4.77 |
| CHEMBL1089322 | — | — | 1 | 4.76 |
| CHEMBL1091957 | — | — | 1 | 4.74 |
| CHEMBL1090900 | — | — | 1 | 4.73 |
| CHEMBL1090597 | — | — | 1 | 4.69 |
| CHEMBL1090368 | — | — | 1 | 4.68 |
| CHEMBL1093231 | — | — | 1 | 4.67 |
| CHEMBL1090596 | — | — | 1 | 4.67 |
| CHEMBL1090899 | — | — | 1 | 4.64 |
| CHEMBL1092261 | — | — | 1 | 4.64 |
| CHEMBL1090591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090564 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1090250 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1092684 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1091972 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1092279 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1090594 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1092685 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1092698 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1093245 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1090595 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1093506 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1093852 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1091956 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1093851 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1093232 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1093872 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1092699 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1093905 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1090898 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1089322 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1091957 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1090900 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL1090597 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL1090368 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL1093231 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1090596 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1090899 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL1092261 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL1090592 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1091230 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1090565 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1093995 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1093850 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1091973 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1092262 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1090251 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1090252 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1090591 | — | IC50 | > | 25000.0 | nM | - |