Assay Detail
Binding
CHEMBL1104717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from human mu opioid receptor expressed in CHOK1 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.21 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094880 | — | — | 1 | 6.85 |
| CHEMBL1096474 | — | — | 1 | 6.75 |
| CHEMBL1095521 | — | — | 1 | 6.33 |
| CHEMBL1094237 | — | — | 1 | 6.19 |
| CHEMBL1096473 | — | — | 1 | 5.94 |
| CHEMBL1096475 | — | — | 1 | 5.21 |
| CHEMBL1095184 | — | — | 1 | - |
| CHEMBL1094860 | — | — | 1 | - |
| CHEMBL1094236 | — | — | 1 | - |
| CHEMBL1095183 | — | — | 1 | - |
| CHEMBL1096675 | — | — | 1 | - |
| CHEMBL1095520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094880 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1096474 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1095521 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL1094237 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL1096473 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL1096475 | — | Ki | = | 6120.0 | nM | 5.21 |
| CHEMBL1095184 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1094860 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1094236 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1095183 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1096675 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1095520 | — | Ki | > | 1000.0 | nM | - |