Assay Detail
Functional
CHEMBL1105343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (CHEMBL612610) ↗| Type | ORGANISM |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.51 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089302 | — | — | 2 | 6.22 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.60 |
| CHEMBL1089502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089302 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1089302 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL1089502 | — | EC50 | > | 41000.0 | nM | - |