Assay Detail
Functional
CHEMBL1105502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.81 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12442 | — | — | 1 | 7.00 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.89 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 5.85 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12442 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 31000.0 | nM | 4.51 |