Assay Detail
Functional
CHEMBL1106971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei after 48 hrs by luminescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Podophyllotoxin analogues active versus Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.80 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076638 | — | — | 1 | 7.29 |
| CHEMBL379989 | RHIZOXIN | — | 1 | 6.82 |
| CHEMBL1076642 | — | — | 1 | 6.77 |
| CHEMBL1076674 | — | — | 1 | 6.66 |
| CHEMBL1076641 | — | — | 1 | 6.34 |
| CHEMBL1076675 | — | — | 1 | 6.00 |
| CHEMBL1076639 | — | — | 1 | 5.47 |
| CHEMBL1076643 | — | — | 1 | 5.35 |
| CHEMBL1076640 | — | — | 1 | 5.28 |
| CHEMBL1076673 | — | — | 1 | 4.57 |
| CHEMBL1076672 | — | — | 1 | 4.51 |
| CHEMBL1076645 | — | — | 1 | 4.50 |
| CHEMBL1076644 | — | — | 1 | - |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | — | 1 | - |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076638 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL379989 | RHIZOXIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1076642 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1076674 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1076641 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1076675 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1076639 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1076643 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1076640 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1076673 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1076672 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1076645 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1076644 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | > | 50000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 50000.0 | nM | - |