Assay Detail
Binding
CHEMBL1106978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells after 90 mins by scintillation counting
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzothiophene H1-antihistamines for the treatment of insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.43 | 8.25 |
| IC50 | 4 | 5.35 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091790 | — | — | 1 | 8.25 |
| CHEMBL1091774 | — | — | 1 | 8.24 |
| CHEMBL1090433 | — | — | 1 | 6.00 |
| CHEMBL1090432 | — | — | 1 | 5.85 |
| CHEMBL1092377 | — | — | 1 | 5.66 |
| CHEMBL1093044 | — | — | 1 | 5.43 |
| CHEMBL1091776 | — | — | 1 | 5.33 |
| CHEMBL564144 | — | — | 1 | 5.28 |
| CHEMBL1091777 | — | — | 1 | 4.55 |
| CHEMBL1092496 | — | — | 1 | - |
| CHEMBL1092495 | — | — | 1 | - |
| CHEMBL1092494 | — | — | 1 | - |
| CHEMBL1091069 | — | — | 1 | - |
| CHEMBL1092126 | — | — | 1 | - |
| CHEMBL1091793 | — | — | 1 | - |
| CHEMBL1091792 | — | — | 1 | - |
| CHEMBL1091791 | — | — | 1 | - |
| CHEMBL1091778 | — | — | 1 | - |
| CHEMBL1091775 | — | — | 1 | - |
| CHEMBL1092812 | — | — | 1 | - |
| CHEMBL1092813 | — | — | 1 | - |
| CHEMBL1093294 | — | — | 1 | - |
| CHEMBL1093058 | — | — | 1 | - |
| CHEMBL1092765 | — | — | 1 | - |
| CHEMBL1092766 | — | — | 1 | - |
| CHEMBL1092767 | — | — | 1 | - |
| CHEMBL1091782 | — | — | 1 | - |
| CHEMBL1092118 | — | — | 1 | - |
| CHEMBL1093607 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091790 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL1091774 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1090433 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL1090432 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1092377 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1093044 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1091776 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL564144 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1091777 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1092496 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092495 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092494 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1091069 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092126 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1091793 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1091792 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1091791 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1091778 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1091775 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092812 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092813 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1093294 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1093058 | — | Ki | > | 10000000.0 | nM | - |
| CHEMBL1092765 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092766 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1092767 | — | Ki | = | 2072000.0 | nM | - |
| CHEMBL1091782 | — | Ki | = | 4759000.0 | nM | - |
| CHEMBL1092118 | — | Ki | > | 10000000.0 | nM | - |
| CHEMBL1093607 | — | Ki | - | — | - |