Assay Detail
Binding
CHEMBL1107083
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Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.04 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091998 | — | — | 1 | 10.49 |
| CHEMBL1091160 | — | — | 1 | 10.33 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.37 |
| CHEMBL50398 | — | — | 1 | 9.12 |
| CHEMBL1091561 | — | — | 1 | 8.80 |
| CHEMBL1091716 | — | — | 1 | 8.79 |
| CHEMBL1091894 | — | — | 1 | 8.67 |
| CHEMBL297947 | — | — | 1 | 8.15 |
| CHEMBL1092047 | — | — | 1 | 7.90 |
| CHEMBL1091895 | — | — | 1 | 7.87 |
| CHEMBL1092400 | — | — | 1 | 7.58 |
| CHEMBL1092839 | — | — | 1 | 7.55 |
| CHEMBL1092062 | — | — | 1 | 7.33 |
| CHEMBL1092647 | — | — | 1 | 7.16 |
| CHEMBL1091896 | — | — | 1 | 7.14 |
| CHEMBL1091997 | — | — | 1 | 6.99 |
| CHEMBL1093457 | — | — | 1 | 6.98 |
| CHEMBL1092911 | — | — | 1 | 6.92 |
| CHEMBL1088826 | — | — | 1 | 5.64 |
| CHEMBL1088825 | — | — | 1 | - |
| CHEMBL1092646 | — | — | 1 | - |
| CHEMBL1091161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091998 | — | Ki | = | 0.0326 | nM | 10.49 |
| CHEMBL1091160 | — | Ki | = | 0.04705 | nM | 10.33 |
| CHEMBL45 | MELATONIN | Ki | = | 0.429 | nM | 9.37 |
| CHEMBL50398 | — | Ki | = | 0.751 | nM | 9.12 |
| CHEMBL1091561 | — | Ki | = | 1.59 | nM | 8.80 |
| CHEMBL1091716 | — | Ki | = | 1.61 | nM | 8.79 |
| CHEMBL1091894 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL297947 | — | Ki | = | 7.07 | nM | 8.15 |
| CHEMBL1092047 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL1091895 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL1092400 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL1092839 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL1092062 | — | Ki | = | 46.2 | nM | 7.33 |
| CHEMBL1092647 | — | Ki | = | 69.3 | nM | 7.16 |
| CHEMBL1091896 | — | Ki | = | 72.2 | nM | 7.14 |
| CHEMBL1091997 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1093457 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1092911 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL1088826 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1088825 | — | Ki | = | 0.00103 | nM | - |
| CHEMBL1092646 | — | Ki | = | 0.00069 | nM | - |
| CHEMBL1091161 | — | Ki | = | 0.00055 | nM | - |