Assay Detail
Functional
CHEMBL1107217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Polio virus type1 Sabin strain Chat infected in african green monkey Vero cells after 2 days by plaque reduction assay
81
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human poliovirus 1 strain Sabin |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 81 | 4.56 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093875 | — | — | 1 | 5.70 |
| CHEMBL1091037 | — | — | 1 | 4.85 |
| CHEMBL1093508 | — | — | 1 | 4.80 |
| CHEMBL1091257 | — | — | 1 | 4.75 |
| CHEMBL1089234 | — | — | 1 | 4.70 |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | 4.64 |
| CHEMBL1091736 | — | — | 1 | 4.62 |
| CHEMBL1093512 | — | — | 1 | 4.60 |
| CHEMBL1092702 | — | — | 1 | 4.52 |
| CHEMBL1095562 | — | — | 1 | 4.46 |
| CHEMBL1093263 | — | — | 1 | 4.46 |
| CHEMBL1093874 | — | — | 1 | 4.39 |
| CHEMBL1091653 | — | — | 1 | 4.38 |
| CHEMBL1093988 | — | — | 1 | 4.33 |
| CHEMBL1090902 | — | — | 1 | 4.30 |
| CHEMBL1092613 | — | — | 1 | 4.05 |
| CHEMBL1093907 | — | — | 1 | 4.05 |
| CHEMBL1089235 | — | — | 1 | - |
| CHEMBL209918 | — | — | 1 | - |
| CHEMBL1093919 | — | — | 1 | - |
| CHEMBL1094255 | — | — | 1 | - |
| CHEMBL1093920 | — | — | 1 | - |
| CHEMBL1090692 | — | — | 1 | - |
| CHEMBL1091651 | — | — | 1 | - |
| CHEMBL1091652 | — | — | 1 | - |
| CHEMBL159895 | — | — | 1 | - |
| CHEMBL1088991 | — | — | 1 | - |
| CHEMBL1095561 | — | — | 1 | - |
| CHEMBL1093553 | — | — | 1 | - |
| CHEMBL1093511 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093875 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1091037 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1093508 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1091257 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1089234 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1091736 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1093512 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1092702 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1095562 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1093263 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1093874 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1091653 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1093988 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1090902 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1093907 | — | EC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL1092613 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1093906 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1643 | RIBAVIRIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL564201 | 6-AZAURIDINE | EC50 | > | 20000.0 | nM | - |
| CHEMBL1093853 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1092703 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL1095561 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1092701 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1090903 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093876 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1091953 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093873 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093507 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1089907 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL564201 | 6-AZAURIDINE | EC50 | > | 20000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093520 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093553 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1090678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1088991 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL159895 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1090692 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1094255 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL209918 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1089235 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093906 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093919 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL1094254 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093920 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1091651 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093511 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1090567 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1093513 | — | EC50 | > | 100000.0 | nM | - |