Assay Detail
Binding
CHEMBL1107672
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Displacement of [125I]7OH-PIPAT from dopamine D2 receptor from rat brain homogenate
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.87 | 9.19 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081746 | — | — | 1 | 9.19 |
| CHEMBL1081409 | — | — | 1 | 9.05 |
| CHEMBL1081687 | — | — | 1 | 9.01 |
| CHEMBL1081867 | — | — | 1 | 8.70 |
| CHEMBL1081023 | — | — | 1 | 8.38 |
| CHEMBL1080490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081746 | — | Ki | = | 0.6457 | nM | 9.19 |
| CHEMBL1081409 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL1081687 | — | Ki | = | 0.9772 | nM | 9.01 |
| CHEMBL1081867 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL1081023 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL1080490 | — | pKi | - | — | - |