Assay Detail
Functional
CHEMBL1107823
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Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Podophyllotoxin analogues active versus Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.78 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.77 |
| CHEMBL1076673 | — | — | 1 | 7.57 |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | — | 1 | 7.12 |
| CHEMBL1076672 | — | — | 1 | 7.10 |
| CHEMBL1076638 | — | — | 1 | 6.80 |
| CHEMBL1076641 | — | — | 1 | 6.80 |
| CHEMBL1076642 | — | — | 1 | 6.75 |
| CHEMBL1076674 | — | — | 1 | 6.66 |
| CHEMBL1076640 | — | — | 1 | 6.62 |
| CHEMBL1076643 | — | — | 1 | 6.48 |
| CHEMBL379989 | RHIZOXIN | — | 1 | 6.46 |
| CHEMBL1076645 | — | — | 1 | 6.44 |
| CHEMBL1076675 | — | — | 1 | 6.28 |
| CHEMBL1076639 | — | — | 1 | 6.07 |
| CHEMBL1076644 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1076673 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1081214 | SUCCINYLPODOPHYLLOTOXIN | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1076672 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1076638 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1076641 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1076642 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1076674 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1076640 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1076643 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL379989 | RHIZOXIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1076645 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1076675 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1076639 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1076644 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 50000.0 | nM | - |