Assay Detail
Functional
CHEMBL1108339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.12 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 8.80 |
| CHEMBL1097497 | — | — | 1 | 8.71 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 8.66 |
| CHEMBL1094212 | — | — | 1 | 8.62 |
| CHEMBL1095522 | — | — | 1 | 8.62 |
| CHEMBL1097496 | — | — | 1 | 8.60 |
| CHEMBL1095196 | — | — | 1 | 8.54 |
| CHEMBL1095504 | — | — | 1 | 8.50 |
| CHEMBL1095831 | — | — | 1 | 8.11 |
| CHEMBL1095832 | — | — | 1 | 8.04 |
| CHEMBL1096991 | — | — | 1 | 7.95 |
| CHEMBL1095195 | — | — | 1 | 7.92 |
| CHEMBL1097315 | — | — | 1 | 7.79 |
| CHEMBL1095197 | — | — | 1 | 7.66 |
| CHEMBL1095505 | — | — | 1 | 7.66 |
| CHEMBL1094546 | — | — | 1 | 7.58 |
| CHEMBL1094545 | — | — | 1 | 7.33 |
| CHEMBL14453 | — | — | 1 | 7.14 |
| CHEMBL1097314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1097497 | — | EC50 | = | 1.94 | nM | 8.71 |
| CHEMBL45 | MELATONIN | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1094212 | — | EC50 | = | 2.37 | nM | 8.62 |
| CHEMBL1095522 | — | EC50 | = | 2.38 | nM | 8.62 |
| CHEMBL1097496 | — | EC50 | = | 2.49 | nM | 8.60 |
| CHEMBL1095196 | — | EC50 | = | 2.89 | nM | 8.54 |
| CHEMBL1095504 | — | EC50 | = | 3.14 | nM | 8.50 |
| CHEMBL1095831 | — | EC50 | = | 7.75 | nM | 8.11 |
| CHEMBL1095832 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL1096991 | — | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL1095195 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1097315 | — | EC50 | = | 16.1 | nM | 7.79 |
| CHEMBL1095197 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL1095505 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1094546 | — | EC50 | = | 26.1 | nM | 7.58 |
| CHEMBL1094545 | — | EC50 | = | 46.2 | nM | 7.33 |
| CHEMBL14453 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1097314 | — | EC50 | > | 1e-05 | nM | - |