Assay Detail
Functional
CHEMBL1108343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.68 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 10.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.31 |
| CHEMBL1097497 | — | — | 1 | 7.69 |
| CHEMBL1094212 | — | — | 1 | 7.58 |
| CHEMBL1097315 | — | — | 1 | 7.40 |
| CHEMBL1095197 | — | — | 1 | 7.06 |
| CHEMBL1097314 | — | — | 1 | 6.87 |
| CHEMBL1095505 | — | — | 1 | 6.79 |
| CHEMBL14453 | — | — | 1 | 6.39 |
| CHEMBL1097496 | — | — | 1 | - |
| CHEMBL1095522 | — | — | 1 | - |
| CHEMBL1095831 | — | — | 1 | - |
| CHEMBL1095832 | — | — | 1 | - |
| CHEMBL1096991 | — | — | 1 | - |
| CHEMBL1095195 | — | — | 1 | - |
| CHEMBL1095196 | — | — | 1 | - |
| CHEMBL1095504 | — | — | 1 | - |
| CHEMBL1094546 | — | — | 1 | - |
| CHEMBL1094545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL45 | MELATONIN | EC50 | = | 0.49 | nM | 9.31 |
| CHEMBL1097497 | — | EC50 | = | 20.6 | nM | 7.69 |
| CHEMBL1094212 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1097315 | — | EC50 | = | 40.2 | nM | 7.40 |
| CHEMBL1095197 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1097314 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1095505 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL14453 | — | EC50 | = | 405.0 | nM | 6.39 |
| CHEMBL1097496 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095522 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095831 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095832 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1096991 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095195 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095196 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1095504 | — | EC50 | > | 1e-05 | nM | - |
| CHEMBL1094546 | — | EC50 | - | — | - | |
| CHEMBL1094545 | — | EC50 | > | 1e-05 | nM | - |