Assay Detail
Functional
CHEMBL1108451
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Antiproliferative activity against human HCT116 cells after 3 days by XTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.27 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.89 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.77 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 5.58 |
| CHEMBL1078221 | — | — | 1 | 5.36 |
| CHEMBL1078316 | — | — | 1 | 4.88 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.87 |
| CHEMBL1078318 | — | — | 1 | 4.75 |
| CHEMBL1078319 | — | — | 1 | 4.67 |
| CHEMBL1078125 | — | — | 1 | 4.65 |
| CHEMBL567578 | — | — | 1 | - |
| CHEMBL1081516 | — | — | 1 | - |
| CHEMBL1080077 | — | — | 1 | - |
| CHEMBL1078315 | — | — | 1 | - |
| CHEMBL1080792 | — | — | 1 | - |
| CHEMBL1078317 | — | — | 1 | - |
| CHEMBL1078126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1078221 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL1078316 | — | IC50 | = | 13340.0 | nM | 4.88 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 13460.0 | nM | 4.87 |
| CHEMBL1078318 | — | IC50 | = | 17730.0 | nM | 4.75 |
| CHEMBL1078319 | — | IC50 | = | 21260.0 | nM | 4.67 |
| CHEMBL1078125 | — | IC50 | = | 22240.0 | nM | 4.65 |
| CHEMBL567578 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1081516 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1080077 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1078315 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1080792 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1078317 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1078126 | — | IC50 | > | 25000.0 | nM | - |