Assay Detail
Binding
CHEMBL1108828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-HSD3 in human testis microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Testis |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL4234) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.59 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387599 | — | — | 1 | 7.00 |
| CHEMBL255168 | — | — | 1 | 5.62 |
| CHEMBL1088987 | — | — | 1 | 5.57 |
| CHEMBL1093484 | — | — | 1 | 5.57 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387599 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL255168 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1088987 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1093484 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL140 | CURCUMIN | IC50 | = | 67300.0 | nM | 4.17 |