Assay Detail
Binding
CHEMBL1109788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of WFYpSPFLE from human Pin1 catalytic domain after 10-20 mins by fluorescence polarization assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (CHEMBL2288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of novel human Pin1 inhibitors (II).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 5.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089602 | — | — | 1 | 8.22 |
| CHEMBL1092489 | — | — | 1 | 6.75 |
| CHEMBL1090715 | — | — | 1 | 6.05 |
| CHEMBL1090714 | — | — | 1 | 5.75 |
| CHEMBL1091805 | — | — | 1 | 5.75 |
| CHEMBL1090379 | — | — | 1 | 5.73 |
| CHEMBL1091060 | — | — | 1 | 5.70 |
| CHEMBL1089685 | — | — | 1 | 5.70 |
| CHEMBL1093344 | — | — | 1 | 5.66 |
| CHEMBL1091804 | — | — | 1 | 5.64 |
| CHEMBL1091064 | — | — | 1 | 5.55 |
| CHEMBL1089698 | — | — | 1 | 5.52 |
| CHEMBL1091467 | — | — | 1 | 5.50 |
| CHEMBL1091827 | — | — | 1 | 5.47 |
| CHEMBL1091059 | — | — | 1 | 5.43 |
| CHEMBL1089033 | — | — | 1 | 5.40 |
| CHEMBL1090380 | — | — | 1 | 5.35 |
| CHEMBL1091063 | — | — | 1 | 5.24 |
| CHEMBL1089008 | — | — | 1 | 5.16 |
| CHEMBL1089034 | — | — | 1 | 5.07 |
| CHEMBL1093345 | — | — | 1 | 5.05 |
| CHEMBL1091065 | — | — | 1 | 5.01 |
| CHEMBL1090728 | — | — | 1 | 4.96 |
| CHEMBL1089699 | — | — | 1 | 4.96 |
| CHEMBL1090719 | — | — | 1 | 4.92 |
| CHEMBL1091322 | — | — | 1 | 4.89 |
| CHEMBL1090378 | — | — | 1 | 4.89 |
| CHEMBL1093715 | — | — | 1 | 4.77 |
| CHEMBL1089009 | — | — | 1 | 4.75 |
| CHEMBL1093045 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089602 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1092489 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL1090715 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL1090714 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1091805 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1090379 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL1091060 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1089685 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1093344 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1091804 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1091064 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1089698 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1091467 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1091827 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL1091059 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL1089033 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1090380 | — | Ki | = | 4430.0 | nM | 5.35 |
| CHEMBL1091063 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL1089008 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1089034 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL1093345 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1091065 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL1089699 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1090728 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1090719 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1091322 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1090378 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL1093715 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1089009 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1093045 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL1090074 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1093716 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL1089369 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL1089035 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL1089942 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL1093343 | — | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL1090075 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL1090718 | — | Ki | = | 103000.0 | nM | - |
| CHEMBL1092490 | — | Ki | - | — | - | |
| CHEMBL1090073 | — | Ki | - | — | - | |
| CHEMBL1093714 | — | Ki | = | 121000.0 | nM | - |
| CHEMBL1093029 | — | Ki | = | 351000.0 | nM | - |