Assay Detail
Binding
CHEMBL1109869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093445 | — | — | 1 | 9.00 |
| CHEMBL1088835 | — | — | 1 | 8.52 |
| CHEMBL1089653 | — | — | 1 | 8.40 |
| CHEMBL1090505 | — | — | 1 | 8.15 |
| CHEMBL1089823 | — | — | 1 | 8.05 |
| CHEMBL1090115 | — | — | 1 | 8.00 |
| CHEMBL1090153 | — | — | 1 | 7.96 |
| CHEMBL1092189 | — | — | 1 | 7.75 |
| CHEMBL1090478 | — | — | 1 | 7.75 |
| CHEMBL1089423 | — | — | 1 | 7.66 |
| CHEMBL1093446 | — | — | 1 | 7.21 |
| CHEMBL1090130 | — | — | 1 | 7.02 |
| CHEMBL1093449 | — | — | 1 | 6.97 |
| CHEMBL1091855 | — | — | 1 | 6.93 |
| CHEMBL1089424 | — | — | 1 | 6.91 |
| CHEMBL1089422 | — | — | 1 | 6.89 |
| CHEMBL1093448 | — | — | 1 | 6.82 |
| CHEMBL1091864 | — | — | 1 | 6.72 |
| CHEMBL1088834 | — | — | 1 | 6.72 |
| CHEMBL1090131 | — | — | 1 | 6.67 |
| CHEMBL1091882 | — | — | 1 | 6.58 |
| CHEMBL1089784 | — | — | 1 | 6.55 |
| CHEMBL1093437 | — | — | 1 | 6.37 |
| CHEMBL1091884 | — | — | 1 | 6.30 |
| CHEMBL1091070 | — | — | 1 | 6.10 |
| CHEMBL1091854 | — | — | 1 | 5.78 |
| CHEMBL1090506 | — | — | 1 | 5.67 |
| CHEMBL1093930 | — | — | 1 | 5.43 |
| CHEMBL1091883 | — | — | 1 | 5.30 |
| CHEMBL1093629 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093445 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1088835 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1089653 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1090505 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1089823 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1090115 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1090153 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1092189 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1090478 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1089423 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1093446 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1090130 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1093449 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1091855 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1089424 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1089422 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1093448 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL1091864 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1088834 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1090131 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL1091882 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL1089784 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1093437 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1091884 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1091070 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1091854 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1090506 | — | IC50 | = | 2125.0 | nM | 5.67 |
| CHEMBL1093930 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1091883 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1093629 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1091534 | — | IC50 | = | 11000.0 | nM | 4.96 |